Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5763416

Title:Gene transfer into bone cells and tissues
Inventors:Bonadio, Jeffrey; Ann Arbor, MI, USA
Goldstein, Steven A.; Ann Arbor, MI, USA
Summary:Described herein is a method of transferring a nucleic acid into bone progenitor cells using a bone-compatible matrix. Methods and materials are disclosed for the in situ transfer of nucleic acids into bone, such that an osteotropic gene is transferred into bone progenitor cells, which results in the stimulation of the progenitor cells to promote bone growth, repair and regeneration in vivo. Therapeutic applications are included for the treatment of various bone-related diseases and defects, such as in the promotion of fracture repair, for use in conjunction with implants, and in the treatment of osteoporosis and osteogenesis imperfecta.
Abstract:
US Patent Website:Click Here for Full Text of Patent
Title Number:US5763416
Application Number:US1994000199780
Date Filed:18/02/1994
Date Published:09/06/1998
Assignee:The Regent of the University of Michigan, Ann Arbor, MI, USA


 
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