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Stem Cell Related Patent Number US5763416
| Title: | Gene transfer into bone cells and tissues | | Inventors: | Bonadio, Jeffrey; Ann Arbor, MI, USA
Goldstein, Steven A.; Ann Arbor, MI, USA | | Summary: | Described herein is a method of transferring a nucleic acid into bone progenitor cells using a bone-compatible matrix. Methods and materials are disclosed for the in situ transfer of nucleic acids into bone, such that an osteotropic gene is transferred into bone progenitor cells, which results in the stimulation of the progenitor cells to promote bone growth, repair and regeneration in vivo. Therapeutic applications are included for the treatment of various bone-related diseases and defects, such as in the promotion of fracture repair, for use in conjunction with implants, and in the treatment of osteoporosis and osteogenesis imperfecta. | | Abstract: | | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US5763416 | | Application Number: | US1994000199780 | | Date Filed: | 18/02/1994 | | Date Published: | 09/06/1998 | | Assignee: | The Regent of the University of Michigan, Ann Arbor, MI, USA |
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