Methods comprising apoptosis inhibitors for the generation of transgenic pigs |
 |
|
|
||||||||||||||||||||||||||||||||||||||||||
| Title: | Method for treating mammals with monopegylated proteins that stimulates megakaryocyte growth and differentiation |
| Inventors: | Bartley, Timothy D.; Thousand Oaks, CA, USA Bogenberger, Jakob M.; Camarillo, CA, USA Bosselman, Robert A.; Thousand Oaks, CA, USA Hunt, Pamela; Thousand Oaks, CA, USA Kinstler, Olaf B.; Thousand Oaks, CA, USA Samal, Babru B.; Moorpark, CA, USA |
| Summary: | This invention discloses mammalian treatment methods involving proteins referred to as megakaryocyte growth and development factors (MGDFs; also generally referred to as Mpl ligands), that have a biological activity of stimulating the growth of megakaryocytes and augmenting the differentiation or maturation of megakaryocytes, ultimately resulting in the production of platelets. Also disclosed are MGDF derivatives comprising MGDF molecules attached to water soluble polymers, such as polyethylene glycol. Methods of preparation and treatment are emphasized. This invention is an expansion of number US5795569, in which the novel properties of MGDFs were introduced. |
| Abstract: | Disclosed are novel proteins, referred to as megakaryocyte growth and development factors (MGDFs; also generally referred to as Mpl ligands), that have a biological activity of stimulating the growth of megakaryocytes and augmenting the differentiation or maturation of megakaryocytes, ultimately to result in the production of platelets. MGDF derivatives comprising MGDF molecules attached to water soluble polymers, such as polyethylene glycol, are also disclosed, along with methods for their preparation. The MGDF proteins and derivatives are useful in methods for treating mammals to increase platelets and/or megakaryocytes. Also disclosed are processes for obtaining the MGDFs in homogeneous form from natural sources and producing them by recombinant genetic engineering techniques from mammals, including humans. |
| US Patent Website: | Click Here for Full Text of Patent |
| Title Number: | US5766581 |
| Application Number: | US1995000413803 |
| Date Filed: | 30/03/1995 |
| Date Published: | 16/06/1998 |
| Assignee: | Amgen Inc., Thousand Oaks, CA, USA |