Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5770414

Title:Regulatable retrovirus system for genetic modification of cells
Inventors:Gage, Fred H.; La Jolla, CA, USA
Ray, Jasodhara; San Diego, CA, USA
Hoshimaru, Minoru; Shiga-ken, Japan
Summary:Described herein is a retroviral vector containing a regulatable transactivator element and a heterologous gene, and methods of its use in the genetic modification of cells. The invention relates to a novel regulatable retroviral vector in which the v-myc oncogene is driven by a tetracycline-controlled transactivator and a human cytomegalovirus minimal promoter fused to tet operator sequences. Further disclosed are methods by which such a vector may be used for the immortalization of adult neuronal progenitor cells and for the regulation of heterologous Producer cell lines which produce high titers of the recombinant retrovirus. Therapeutic and experimental applications are provided for the use of this oncogene in rendering neuronal precursor cells immortal until the transactivator is switched off.
Abstract:
US Patent Website:Click Here for Full Text of Patent
Title Number:US5770414
Application Number:US1996000602203
Date Filed:20/02/1996
Date Published:23/06/1998
Assignee:The Regents of the University of California, Oakland, CA, USA


 
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