Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5780300

Title:Manipulation of non-terminally differentiated cells using the notch pathway
Inventors:Artavanis-Tsakonas, Spyridon; Hamden, CT, USA
Fortini, Mark Edward; New Haven, CT, USA
Matsuno, Kenji; New Haven, CT, USA
Summary:Described herein is a method of expanding a human precursor cell using a Notch function agonist. The invention relates to a process for the expansion of non-terminally differentiated cells using agonists of the Notch function to inhibit the differentiation of the cells without inhibiting their proliferative mitotic activity. Methods and materials are elucidated, as are therapeutic applications for the use of such expanded cells as a source of non-differentiated cell populations in recombinant gene therapy.
Abstract:The present invention is directed to methods for the expansion of non-terminally differentiated cells (precursor cells) using agonists of Notch function, by inhibiting the differentiation of the cells without inhibiting proliferation (mitotic activity) such that an expanded population of non-terminally differentiated cells is obtained. The cells are preferably stem or progenitor cells. These expanded cells can be used in cell replacement therapy to provide desired cell populations and help in the regeneration of diseased and/or injured tissues. The expanded cell populations can also be made recombinant and used for gene therapy, or can be used to supply functions associated with a particular precursor cell or its progeny cell.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5780300
Application Number:US1995000537210
Date Filed:29/09/1995
Date Published:14/07/1998
Assignee:Yale University, New Haven, CT, USA


 
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