Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5786323

Title:Use of stem cell factor and soluble interleukin-6 receptor to induce the development of hematopoietic stem cells
Inventors:Nakahata, Tatsutoshi; Tokyo, Japan
Summary:Described herein are methods for the ex vivo expansion of multipotent hematopoietic cells according to a process of culturing the cells with a combination of cytokines such as interleukin-6, soluble interleukin-6 receptor and stem cell factor to induce the proliferation and differentiation of hematopoietic stem cells, from which erythroid cell may be produced. Further disclosed are methods by which stem cell factor in combination with gp130 signaling supports such proliferation, differentiation and terminal maturation of erythroid cells from normal human hematopoietic stem cells in the absence of erythropoietin. Therapeutic and experimental applications are provided.
Abstract:Stem cell factor in combination with gp130 signaling supports proliferation, differentiation and terminal maturation of erythroid cells from normal human hematopoietic stem cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5786323
Application Number:US1996000728100
Date Filed:09/10/1996
Date Published:28/07/1998
Assignee:Amgen Inc., Thousand Oaks, CA, USA Tosoh Corporation, Tokyo, Japan


 
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