Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5786336

Title:Target-selective protocols based on mimics
Inventors:Kauvar, Lawrence M.; San Francisco, CA, USA
Lyttle, Matthew H.; Point Reyes Station, CA, USA
Morgan, Amy S.; Oakland, CA, USA
Borch, Richard F.; Pittsford, NY, USA
Summary:This invention introduces novel glutathione analogues and methods of their use in binding glutathione-S-transferase enzymes. Described herein is a method to potentiate the effect of a chemotherapeutic agent in a tumor cell according to a process by which the chemotherapeutic agent is administered to the tumor cell in combination with a potentiating amount of a compound, or of an amide, ester or hybrid amide/ester thereof. Chemical properties and configurations of the compound are disclosed, as are methods by which it may be used to stimulate the production of granulocyte macrophage progenitors in the bone marrow of a subject. Therapeutic applications to the treatment of various cancers are included.
Abstract:
US Patent Website:Click Here for Full Text of Patent
Title Number:US5786336
Application Number:US1994000305993
Date Filed:19/09/1994
Date Published:28/07/1998
Assignee:Terrapin Technologies, Inc., South San Francisco, CA, USA


 
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