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Stem Cell Related Patent Number US5786336
| Title: | Target-selective protocols based on mimics | | Inventors: | Kauvar, Lawrence M.; San Francisco, CA, USA
Lyttle, Matthew H.; Point Reyes Station, CA, USA
Morgan, Amy S.; Oakland, CA, USA
Borch, Richard F.; Pittsford, NY, USA | | Summary: | This invention introduces novel glutathione analogues and methods of their use in binding glutathione-S-transferase enzymes. Described herein is a method to potentiate the effect of a chemotherapeutic agent in a tumor cell according to a process by which the chemotherapeutic agent is administered to the tumor cell in combination with a potentiating amount of a compound, or of an amide, ester or hybrid amide/ester thereof. Chemical properties and configurations of the compound are disclosed, as are methods by which it may be used to stimulate the production of granulocyte macrophage progenitors in the bone marrow of a subject. Therapeutic applications to the treatment of various cancers are included. | | Abstract: | | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US5786336 | | Application Number: | US1994000305993 | | Date Filed: | 19/09/1994 | | Date Published: | 28/07/1998 | | Assignee: | Terrapin Technologies, Inc., South San Francisco, CA, USA |
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