Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5789539

Title:Chemokine-like proteins and methods of use
Inventors:Daly, Thomas J.; Framingham, MA, USA
Summary:This invention introduces novel chemokine-like proteins, methods and uses thereof. The proteins are described as including two or more newly discovered active domains from different chemokines, such that the active domains are regions of several contiguous amino acids that are necessary for the ability of the chemokines to suppress the proliferation of actively dividing myeloid cells, such as myeloid progenitor cells, myeloid stem cells, and leukemic cells. Claims of the invention include high myelosuppressive activity exhibited by the chemokine-like proteins.
Abstract:The invention relates to novel chemokine-like proteins that include two or more newly discovered active domains from different chemokines. Active domains are regions of several contiguous amino acids that are necessary for chemokines' ability to suppress the proliferation of actively dividing myeloid cells, e.g., myeloid progenitor cells, myeloid stem cells, and leukemic cells. The new chemokine-like proteins provide higher myelosuppressive activity than naturally occurring, wild-type chemokines.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5789539
Application Number:US1995000482111
Date Filed:07/06/1995
Date Published:04/08/1998
Assignee:Repligen Corporation, Cambridge, MA, USA


 
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