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| Title: | Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation |
| Inventors: | Bartley, Timothy D.; Thousand Oaks, CA, USA Bogenberger, Jakob M.; Camarillo, CA, USA Bosselman, Robert A.; Thousand Oaks, CA, USA Hunt, Pamela; Thousand Oaks, CA, USA Kinstler, Olaf B.; Oxnard, CA, USA Samal, Babru B.; Moorpark, CA, USA |
| Summary: | This invention discloses the properties of novel proteins, referred to as megakaryocyte growth and development factors. Such MGDFs are also generally known as Mpl ligands or thrombopoietin, that have a biological activity of stimulating the growth of megakaryocytes and augmenting the differentiation or maturation of megakaryocytes, ultimately resulting in the production of platelets. Also described are MGDF derivatives comprising MGDF molecules attached to water soluble polymers, such as polyethylene glycol, along with methods for their preparation. Further descriptions include processes for obtaining the MGDFs in homogeneous form from natural sources and producing them by recombinant genetic engineering techniques from mammals, including humans. |
| Abstract: | Disclosed are novel proteins, referred to as megakaryocyte growth and development factors (MGDFs; also generally referred to as Mpl ligands or thrombopoietin, that have a biological activity of stimulating the growth of megakaryocytes and augmenting the differentiation or maturation of megakaryocytes, ultimately to result in the production of platelets. MGDF derivatives comprising MGDF molecules attached to water soluble polymers, such as polyethylene glycol, are also disclosed, along with methods for their preparation. Also disclosed are processes for obtaining the MGDFs in homogeneous form from natural sources and producing them by recombinant genetic engineering techniques from mammals, including humans. |
| US Patent Website: | Click Here for Full Text of Patent |
| Title Number: | US5795569 |
| Application Number: | US1994000321488 |
| Date Filed: | 12/10/1994 |
| Date Published: | 18/08/1998 |
| Assignee: | Amgen Inc., Thousand Oaks, CA, USA |