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Stem Cell Related Patent Number US5798387
Title: | Amino acid derivatives | Inventors: | Ishizuka, Masaaki; Mishima, Japan
Kawazu, Masaji; Numazu, Japan
Katsumi, Toshiaki; Himeji, Japan
Fuse, Yoshihide; Himeji, Japan
Maeda, Kenji; Tokyo, Japan
Takeuchi, Tomio; Tokyo, Japan | Summary: | This invention introduces novel T-cell growth-promoting amino acid derivatives and their salts, methods and uses thereof. The derivatives are described herein as being immunomodulatory, anticancer agents and hematopoietic stem cell growth promoters which stimulate the proliferation and physiological activities of hematopoietic stem cells and of T cells in mammals. Claims of the invention include a capacity of such derivatives for chemical synthesis, immunomodulation, an antitumor activity and a carcinostatic activity. Therapeutic applications are proposed for a wide variety of diseases. | Abstract: | A novel amino acid derivative represented by the general formula (I) shown below or a salt thereof have now been provided by chemical synthesis, and it has been found that these new compounds stimulate proliferation and physiological activities of the T cells of mammals, have an immunomodulating activity and also have an antitumor activity or a carcinostatic activity. It has also been found that these new compounds have an effect of stimulating the proliferation of hematopoietic stem cells. STR1 wherein y is 0 or 1; R.sup.1 represents an unsubstituted C.sub.1 -C.sub.8 alkyl group or others; R.sup.2 represents a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group or others; R.sup.3 represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group or others; R.sup.4 represents a hydrogen atom, a C.sub.1 -C.sub.3 alkyl group or others; R.sup.5 represents a group --OR.sup.42, a group STR2 or others. | US Patent Website: | Click Here for Full Text of Patent | Title Number: | US5798387 | Application Number: | US1996000753381 | Date Filed: | 25/11/1996 | Date Published: | 25/08/1998 | Assignee: | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Tokyo, Japan |
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