Methods comprising apoptosis inhibitors for the generation of transgenic pigs

Stem Cell Clinic
Patient Application
FAQ
Contact
Locations
News
Videos
Research
Patents
3D Culture/Scaffold
Administration
Differentiation
Expansion
Extraction/Preservation
Mobilization
Type
USE
 


Stem Cell Related Patent Number US5798387

Title:Amino acid derivatives
Inventors:Ishizuka, Masaaki; Mishima, Japan
Kawazu, Masaji; Numazu, Japan
Katsumi, Toshiaki; Himeji, Japan
Fuse, Yoshihide; Himeji, Japan
Maeda, Kenji; Tokyo, Japan
Takeuchi, Tomio; Tokyo, Japan
Summary:This invention introduces novel T-cell growth-promoting amino acid derivatives and their salts, methods and uses thereof. The derivatives are described herein as being immunomodulatory, anticancer agents and hematopoietic stem cell growth promoters which stimulate the proliferation and physiological activities of hematopoietic stem cells and of T cells in mammals. Claims of the invention include a capacity of such derivatives for chemical synthesis, immunomodulation, an antitumor activity and a carcinostatic activity. Therapeutic applications are proposed for a wide variety of diseases.
Abstract:A novel amino acid derivative represented by the general formula (I) shown below or a salt thereof have now been provided by chemical synthesis, and it has been found that these new compounds stimulate proliferation and physiological activities of the T cells of mammals, have an immunomodulating activity and also have an antitumor activity or a carcinostatic activity. It has also been found that these new compounds have an effect of stimulating the proliferation of hematopoietic stem cells. STR1 wherein y is 0 or 1; R.sup.1 represents an unsubstituted C.sub.1 -C.sub.8 alkyl group or others; R.sup.2 represents a hydrogen atom, a C.sub.1 -C.sub.5 alkyl group or others; R.sup.3 represents a hydrogen atom, a C.sub.1 -C.sub.8 alkyl group or others; R.sup.4 represents a hydrogen atom, a C.sub.1 -C.sub.3 alkyl group or others; R.sup.5 represents a group --OR.sup.42, a group STR2 or others.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5798387
Application Number:US1996000753381
Date Filed:25/11/1996
Date Published:25/08/1998
Assignee:Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Tokyo, Japan


 
Copyright © 2007 The Institute for Cellular Medicine  6/22/2021