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Stem Cell Related Patent Number US5806529

Title:Bone marrow transplantation
Inventors:Reisner, Yair; Old Jaffa, Israel
Martelli, Massimo; Perugia, Italy
Summary:Described herein is a method of bone marrow transplantation by which a high dose of stem cells is administered to an intensively conditioned host. The invention relates to a method for bone marrow transplantation from an HLA-nonmatched donor to a patient according to a process of conditioning the patient under a suitable regimen followed by the transplant of a very large dose of stem cells which is at least approximately 3-fold greater than the conventional doses used in T cell-depleted bone marrow transplantation. Further disclosed are methods by which the patient is conditioned under lethal or supralethal conditions for the treatment of malignant or non-malignant diseases, or under sublethal conditions for the treatment of non-malignant diseases. Claims of the invention include an improved transplantation response in the patient.
Abstract:The present invention provides a method for bone marrow transplantation from an HLA-nonmatched donor to a patient which comprises conditioning the patient under a suitable regimen followed by transplant of a very large dose of stem cells which is at least about 3-fold greater than the conventional doses used in T cell-depleted bone marrow transplantation. The patient is conditioned under lethal or supralethal conditions for the treatment of malignant or non-malignant diseases, or under sublethal conditions for the treatment of non-malignant diseases. The transplant may consist of T cell-depleted bone marrow stem cells and T cell-depleted stem cell-enriched peripheral blood cells from the HLA-nonmatched donor. preferably a relative of the patient, which donor was previously treated with a drug, e.g. a cytokine such as granulocyte colony-stimulating factor (G-CSF).
US Patent Website:Click Here for Full Text of Patent
Title Number:US5806529
Application Number:US1994000333393
Date Filed:02/11/1994
Date Published:15/09/1998
Assignee:Yeda Research and Development Co. Ltd., Rehovot, Israel


 
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