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Stem Cell Related Patent Number US5806529
| Title: | Bone marrow transplantation | | Inventors: | Reisner, Yair; Old Jaffa, Israel
Martelli, Massimo; Perugia, Italy | | Summary: | Described herein is a method of bone marrow transplantation by which a high dose of stem cells is administered to an intensively conditioned host. The invention relates to a method for bone marrow transplantation from an HLA-nonmatched donor to a patient according to a process of conditioning the patient under a suitable regimen followed by the transplant of a very large dose of stem cells which is at least approximately 3-fold greater than the conventional doses used in T cell-depleted bone marrow transplantation. Further disclosed are methods by which the patient is conditioned under lethal or supralethal conditions for the treatment of malignant or non-malignant diseases, or under sublethal conditions for the treatment of non-malignant diseases. Claims of the invention include an improved transplantation response in the patient. | | Abstract: | The present invention provides a method for bone marrow transplantation from an HLA-nonmatched donor to a patient which comprises conditioning the patient under a suitable regimen followed by transplant of a very large dose of stem cells which is at least about 3-fold greater than the conventional doses used in T cell-depleted bone marrow transplantation. The patient is conditioned under lethal or supralethal conditions for the treatment of malignant or non-malignant diseases, or under sublethal conditions for the treatment of non-malignant diseases. The transplant may consist of T cell-depleted bone marrow stem cells and T cell-depleted stem cell-enriched peripheral blood cells from the HLA-nonmatched donor. preferably a relative of the patient, which donor was previously treated with a drug, e.g. a cytokine such as granulocyte colony-stimulating factor (G-CSF). | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US5806529 | | Application Number: | US1994000333393 | | Date Filed: | 02/11/1994 | | Date Published: | 15/09/1998 | | Assignee: | Yeda Research and Development Co. Ltd., Rehovot, Israel |
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