Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5814440

Title:Methods of obtaining compositions enriched for hematopoietic stem cells, antibodies for use therein, compositions derived therefrom and methods of use thereof
Inventors:Hill, Beth Louis; Mountain View, CA, USA
Rozler, Elen; Mountain View, CA, USA
Chen, Benjamin P.; Fremont, CA, USA
Summary:This invention introduces a novel cellular composition comprised of EM10 positive cells, methods and uses thereof. Described herein is a novel antibody, designated ?aEM10, and a hybridoma cell line that produces the ?aEM10 antibody. Further disclosed are methods of producing the compositions enriched for hematopoietic stem cells, via a process which employs a separation technique utilizing the ?aEM10 antibodies which are specific for the unique EM10 cell marker that is expressed on stem and progenitor cells, while being less accessible or absent on more mature cells. Further provided are cell compositions enriched for EM10+ cells. Therapeutic applications are included for the isolation and assay of hematopoietic stem cells and for the treatment of genetic diseases associated with hematopoietic cells such as sickle cell anaemia.
Abstract:This invention provides a novel antibody, designated .alpha.EM10, and a hybridoma cell line that produces the .alpha.EM10 antibody. Also provided are methods to obtain compositions enriched for hematopoietic stem cells. The methods employ a separation technique utilizing antibodies (.alpha.EM10) specific for a unique cell marker (EM10) that is expressed on stem and progenitor cells, while being less accessible or absent on more mature cells. Further provided are cell compositions enriched for EM10+ cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5814440
Application Number:US1997000806380
Date Filed:27/02/1997
Date Published:29/09/1998
Assignee:SyStemix, Inc., Palo Alto, CA, USA


 
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