Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5814500

Title:Delivery construct for antisense nucleic acids and methods of use
Inventors:Dietz, Harry C.; Towson, MD, USA
Summary:Described herein is a nucleic acid construct expressing antisense nucleic acid, methods and uses thereof. The invention relates to a novel nucleic acid construct for delivery of antisense targeting sequences, such that the construct includes intact stem loop structures and an antisense nucleic acid, or, optionally, an additional ribozyme nucleic acid. Therapeutic applications of such allele-specific targeting are included for the inhibition of selected genes in a cell, and for use in combination with replacement gene therapy.
Abstract:A novel nucleic acid construct for delivery of antisense targeting sequences is provided. The construct includes intact stem loop structures and an antisense nucleic acid. Optionally, a ribozyme nucleic acid is included in the construct. The construct is useful for inhibition of selected genes in a cell. This allele-specific targeting is also useful in combination with replacement gene therapy.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5814500
Application Number:US1996000742943
Date Filed:31/10/1996
Date Published:29/09/1998
Assignee:The Johns Hopkins University School of Medicine, Baltimore, MD, USA


 
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