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Stem Cell Related Patent Number US5817912
| Title: | Transgenic mice with disrupted NPY Y1 receptor genes | | Inventors: | Pedrazzini, Thierry; Morrens, Switzerland
Brunner, Hans R.; Pully, Switzerland | | Summary: | Described herein is a DNA construct for the targeted inactivation of a neuropeptide Y receptor gene. The invention relates to a DNA construct comprising a disrupted mouse NPY Y1 receptor gene, wherein the disruption is the result of the insertion of a heterologous marker sequence into the gene such that the protein encoded by the disrupted mouse NPY Y1 receptor gene does not bind to NPY. Further disclosed are transgenic nonhuman mammals which have been engineered by homologous recombination to be deficient in the expression of the specific neuropeptide receptor. Also provided are the DNA constructs and engineered embryonic stem cells employed to produce such mammals, and assays which utilize either the animals themselves or tissue derived therefrom. Therapeutic applications are included in drug screening, especially for agents that reduce food consumption. | | Abstract: | The present invention is directed to transgenic animals which have been engineered by homologous recombination to be deficient in the expression of the neuropeptide Y Y1 receptor. The invention encompasses the DNA constructs and engineered embryonic stem cells used to produce the animals, the transgenic animals themselves, and assays which utilize either the animals or tissues derived from the animals. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US5817912 | | Application Number: | US1997000784289 | | Date Filed: | 16/01/1997 | | Date Published: | 06/10/1998 | | Assignee: | B.M.R.A. Corporation B.V. Netherlands |
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