Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5821108

Title:Enrichment for a thymocyte subset having progenitor cell activity using c-kit as a selection marker
Inventors:Akashi, Koichi; Palo Alto, CA, USA
Weissman, Irving; Redwood City, CA,
Summary:Described herein is a population of thymocyte progenitor cells, methods and uses thereof. The invention relates to a subpopulation in the CD4+ 8+ (DP) thymic blast population which is the precursor for thymic T cells, and in which all such progenitors are c-kit+. Further disclosed are properties of the c-kit+ subset which expresses lower levels of CD4 and CD8 than the large and small DP c-kit- cells, such that the DPint c-kit+ cells differentiate to thymic T cells rapidly upon contact with heterogenous thymic stromal cell cultures. Claims of the invention include an in vivo maturation period of 4 days. Therapeutic and experimental applications of such progenitor cells as a source of mature CD4+ and CD8+T cells are included.
Abstract:
US Patent Website:Click Here for Full Text of Patent
Title Number:US5821108
Application Number:US1995000418534
Date Filed:07/04/1995
Date Published:13/10/1998
Assignee:The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA, USA


 
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