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Stem Cell Related Patent Number US5821108
| Title: | Enrichment for a thymocyte subset having progenitor cell activity using c-kit as a selection marker | | Inventors: | Akashi, Koichi; Palo Alto, CA, USA
Weissman, Irving; Redwood City, CA, | | Summary: | Described herein is a population of thymocyte progenitor cells, methods and uses thereof. The invention relates to a subpopulation in the CD4+ 8+ (DP) thymic blast population which is the precursor for thymic T cells, and in which all such progenitors are c-kit+. Further disclosed are properties of the c-kit+ subset which expresses lower levels of CD4 and CD8 than the large and small DP c-kit- cells, such that the DPint c-kit+ cells differentiate to thymic T cells rapidly upon contact with heterogenous thymic stromal cell cultures. Claims of the invention include an in vivo maturation period of 4 days. Therapeutic and experimental applications of such progenitor cells as a source of mature CD4+ and CD8+T cells are included. | | Abstract: | | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US5821108 | | Application Number: | US1995000418534 | | Date Filed: | 07/04/1995 | | Date Published: | 13/10/1998 | | Assignee: | The Board of Trustees of the Leland Stanford Junior University, Palo Alto, CA, USA |
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