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Stem Cell Related Patent Number US5824084
| Title: | Method of preparing a composite bone graft | | Inventors: | Muschler, George Frederick; Cleveland Heights, OH, USA | | Summary: | Described herein are composite bone graft preparations, methods and uses thereof. The invention relates to a composite bone graft that is prepared according to a process by which a bone marrow aspirate suspension is passed through a porous, biocompatible, implantable substrate to provide a composite bone graft having an enriched population of connective tissue progenitor cells. Claims of the invention include a reduced number of invasive procedures needed by the graftee as a result of this process which is performed intraoperatively, and an improved composite graft containing an enriched population of connective tissue progenitor cells and a greater number of connective tissue progenitor cells per unit volume than that found in the original bone marrow aspirate. Also provided is a kit including the apparatus used in preparing the composite bone graft. Therapeutic applications are included for a variety of bone related diseases and disorders. | | Abstract: | | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US5824084 | | Application Number: | US1996000675498 | | Date Filed: | 03/07/1996 | | Date Published: | 20/10/1998 | | Assignee: | The Cleveland Clinic Foundation, Cleveland, OH, USA |
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