Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5827740

Title:Adipogenic differentiation of human mesenchymal stem cells
Inventors:Pittenger, Mark F.; Severna Park, MD, USA
Summary:This invention describes a method of inducing the differentiation of human mesenchymal stem cells (hMSCs) into adipocytes by treatment with a glucocorticoid and an agent for increasing intracellular levels of cyclic adenosine monophosphate. The agent is described herein as a compound which either stimulates cAMP production or inhibits cAMP degradation such as in phosphodiesterase inhibition. Also provided are methods of isolating the adipocytes from the remaining hMSCs. Therapeutic applications are included for the use of such cells of the adipogenic lineage in implantation such as for reconstructive surgery.
Abstract:A composition which comprises human mesenchymal stem cells which have the potential to differentiate into cells of more than one connective tissue type and a composition which induces cells from the mesenchymal stem cell population to differentiate into the adipogenic lineage, and a process for inducing such differentiation. The composition for inducing such differentiation comprises a glucocorticoid and a compound which stimulates cAMP production or inhibits cAMP degradation (such as a phosphodiesterase inhibitor). The process can further include isolating the adipocytes from remaining hMSCs.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5827740
Application Number:US1996000700753
Date Filed:30/07/1996
Date Published:27/10/1998
Assignee:Osiris Therapeutics, Inc., Baltimore, MD, USA


 
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