Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5830755

Title:T-cell receptors and their use in therapeutic and diagnostic methods
Inventors:Nishimura, Michael; Rockville, MD, USA
Rosenberg, Steven A.; Potomac, MD, USA
Summary:Described herein are T cell receptor alpha and beta chains, related nucleic acids, methods and uses thereof. The invention relates to nucleic acid sequences for T-cell receptors which recognize tumor associated antigens, specifically, melanoma antigens. Further disclosed are properties of T-cells and stem cells expressing the antigen specific T-cell receptors or chimeric receptors. Therapeutic applications are included for the use of such ? and ? chains in pharmaceutical compositions for the prevention or treatment of specific types of cancer such as lung, melanoma, ovarian, colon, brain or kidney tumors.
Abstract:The present invention provides nucleic acid sequences for T-cell receptors which recognize tumor associated antigens. In particular, T-cell receptors which recognize melanoma antigens. This invention also provides T-cells expressing the antigen specific T-cell receptors. In addition, this invention provides stem cells expressing the antigen specific T-cell receptors or chimeric receptors. This invention further relates to therapeutic and diagnostic compositions and methods employing the T-cell receptors and chimeric receptors provided herein.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5830755
Application Number:US1995000411098
Date Filed:27/03/1995
Date Published:03/11/1998
Assignee:The USA as represented by the Secretary of the Department of Health and Human Services, Washington, DC, USA


 
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