Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5830850

Title:Methods for the treatment of bone resorption disorders, including osteoporosis
Inventors:Gelb, Bruce D.; Dobbs Ferry, NY, USA
Chapman, Harold; Newton, MA, USA
Desnick, Robert J.; New York, NY, USA
Summary:This invention describes methods for ameliorating the symptoms of bone-resorption disorders via the treatment of osteoclasts with an inhibitor of cathepsin K. Detailed herein are procedures and compositions for addressing such bone resorption disorders as osteoporosis, the various arthritides, periodontal disease, and damage caused by macrophage-mediated inflammatory processes. Also included are methods and compositions for the specific inhibition of cathepsin K activity, coupled with the specific inhibition of at least a second activity involved in the bone resorption and/or macrophage-mediated inflammatory processes. Also described is the inhibition of both cathepsin K and cathepsin S activity. Further provided are methods for contacting a compound capable of specifically inhibiting cathepsin K activity to an osteoclast for a time sufficient to inhibit the cathepsin K activity so that symptoms of the bone resorption disorder are ameliorated.
Abstract:The present invention relates to methods and compositions for the amelioration of symptoms caused by bone resorption disorders, including but not limited to osteoporosis, arthritides and periodontal disease, and damage caused by macrophage-mediated inflammatory processes. In one embodiment, the methods and compositions of the invention include methods and compositions for the specific inhibition of cathepsin K activity. In an additional embodiment, the methods and compositions of the invention include methods and compositions for the specific inhibition of cathepsin K activity coupled with specific inhibition of at least a second activity involved in the bone resorption and/or macrophage-mediated inflammatory processes. In a particular embodiment, the methods and compositions of the invention include methods and compositions for the specific inhibition of cathepsin K and cathepsin S activity.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5830850
Application Number:US1996000704473
Date Filed:28/08/1996
Date Published:03/11/1998
Assignee:Mount Sinai School of Medicine of the City of New York, New York, NY, USA Brigham and Women's Hospital, Boston, MA, USA


 
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