Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5834441

Title:Adeno-associated viral (AAV) liposomes and methods related thereto
Inventors:Philip, Ramila; Redwood City, CA, USA
Summary:Described herein are liposomes containing an adeno-associated viral (AAV) plasmid, methods and uses thereof. The invention relates to a process of introducing a genetic sequence of interest into a host cell via the use of a cationic liposome comprised of lipid material and an AAV plasmid which in turn is comprised of a terminal repeat of the AAV genome. Further disclosed are methods by which such genetic material may be introduced into stem cells, T cells, lymphocytes, primary tumor cells and tumor cell lines by use of AAV liposomes for the treatment of cancer, HIV infection, autoimmune disease or genetic abnormalities.
Abstract:A composition for genetic manipulation which comprises a liposome comprised of lipid material, and adeno-associated viral (AAV) material. Typically, the AAV material is plasmid, and comprises a terminal repeat of the AAV genome. Methods are disclosed for introducing genetic material into cells by use of AAV liposomes. Accordingly, genetic material was introduced and integrated into stem cells, T cells, primary tumor cells, or tumor cell lines.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5834441
Application Number:US1994000305221
Date Filed:12/09/1994
Date Published:10/11/1998
Assignee:Rhone-Poulenc Rorer Pharmaceuticals Inc., Collegeville, PA, USA


 
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