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Stem Cell Related Patent Number US5837507
| Title: | Hox-induced enhancement of in vivo and in vitro proliferative capacity and gene therapeutic methods | | Inventors: | Largman, Corey; Berkley, CA, USA
Lawrence, Hugh Jeffrey; Lafayette, CA, USA
Humphries, R. Keith; Vancouver, Canada
Sauvageau, Guy; Montreal, P.O., Canada | | Summary: | Described herein is a stem cell which is transduced to express the HOX gene and which exhibits enhanced proliferative capacity. The invention relates to stem cells transduced specifically with the HOXB4 gene and which exhibit an enhanced in vitro and in vivo ability for self-regeneration as well as the capacity to generate higher-numbers of tranplantable pluripotent hematopoietic stem cells when compared to control and nonmanipulated cells. Further disclosed are properties of this type of stem cell and of its modification for expressing an exogenous gene, wherein the particular HOX gene is selected from the group consisting of the class HOXA, HOXB, HOXC, and HOXD genes. Further claims of the invention include an enhanced ability of the modified stem cell to proliferate into an expanded population of pluripotent stem cells. Therapeutic applications of such modified stem cells are included for bone marrow reconstitution without the risk of leukemia, and as carriers for therapeutic genes. | | Abstract: | Stem cells transduced with HOXB4 exhibit enhanced in vitro and in vivo ability for self-regeneration and generate higher-numbers of tranplantable pluripotent hematopoietic stem cells relative to control and nonmanipulated cells. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US5837507 | | Application Number: | US1995000557973 | | Date Filed: | 13/11/1995 | | Date Published: | 17/11/1998 | | Assignee: | The Regents of the University of California, Oakland, CA, USA |
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