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| Title: | Phenotypic characterization of the hematopoietic stem cell |
| Inventors: | Terstappen, Leon W.; Huntingdon Valley, PA, USA Loken, Michael R.; Mercer Island, WA, USA Huang, Shiang; San Ramon, CA, USA Olweus, Johanna; Fremont, CA, USA Lund-Johansen, Fridtjof; Fremont, CA, USA |
| Summary: | Described herein is a population of human cells enriched with hematopoietic stem cells (HSCs) but free of mature progenitor cells. The invention relates to a population of cells that are capable of limited self-renewal and of differentiating into all elements of the hematopoietic system, and which are characterized by the phenotype CD34+ /CD38- and more preferably CD34+ /CD38- /HLA-DR+. Claims of the invention include the expression of CD13, CD33 and CD71 by the cells. Therapeutic applications are included for autologous bone marrow reconstitution after ablative treatment and in gene therapy. |
| Abstract: | One or more population of cells enriched for human hematopoietic stem cells is disclosed. HSC in this population of cells are capable of limited self-renewal and are capable of differentiating into all elements of the hematopoietic system. This population of cells has the phenotype of CD34.sup.+ /CD38.sup.- and more preferably CD34.sup.+ /CD38.sup.- /HLA-DR.sup.+. Cells within this population have been found to express CD13, CD33 and CD71. Hematopoietic stem cells can be used in a number of therapies, including autologous transplantation and in gene therapy. |
| US Patent Website: | Click Here for Full Text of Patent |
| Title Number: | US5840580 |
| Application Number: | US1997000856406 |
| Date Filed: | 14/05/1997 |
| Date Published: | 24/11/1998 |
| Assignee: | Becton Dickinson and Company, Franklin Lakes, NJ, USA |