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Stem Cell Related Patent Number US5843423
| Title: | Methods of stimulating hematopoietic cells with flt3-ligand | | Inventors: | Lyman, Stewart D.; Seattle, WA, USA
Beckmann, M. Patricia; Poulsbo, WA, USA | | Summary: | Described herein are methods of stimulating the proliferation of hematopoietic cells with isolated ligands for flt 3 receptors. The invention relates to ligands for flt3 receptors which are capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells. Further disclosed are properties of specific growth factors and fusion proteins, the flt3-L as an isolated protein, the DNA encoding the flt3-L, host cells transfected with the cDNAs encoding flt3-L, compositions comprising flt3-L, methods of improving gene transfer to a mammal using flt3-L, and methods of improving transplantations using flt3-L. Therapeutic applications are included for the treatment of anemia, AIDS and various cancers. | | Abstract: | Ligands for flt3 receptors capable of transducing self-renewal signals to regulate the growth, proliferation or differentiation of progenitor cells and stem cells are disclosed. The invention is directed to flt3-L as an isolated protein, the DNA encoding the flt3-L, host cells transfected with cDNAs encoding flt3-L, compositions comprising flt3-L, methods of improving gene transfer to a mammal using flt3-L, and methods of improving transplantations using flt3-L. Flt3-L finds use in treating patients with anemia, AIDS and various cancers. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US5843423 | | Application Number: | US1997000993962 | | Date Filed: | 18/12/1997 | | Date Published: | 01/12/1998 | | Assignee: | Immunex Corporation, Seattle, WA, USA |
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