Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5843425

Title:Transplantation and graft-versus-host-disease
Inventors:Sachs, David H.; Newton, MA, USA
Arn, J. Scott; North Andover, MA, USA
Lorf, Thomas; Hardegsen/Gladebeck, Germany
Summary:This invention introduces a novel preparation of swine donor tissue, methods and uses thereof. Described herein are combined hematopoietic stem cells and T cells that are contacted with swine tissue and which contain an antibody that binds to the epitope recognized by the mAb 2-16-15 monoclonal antibody, thereby facilitating the depletion of T cells. Claims of the invention include greater T cell depletion efficiency than that of regular mAB 2-16-15, without depleting hematopoietic stem cells. Therapeutic applications include human transplantation treatment in the prevention or alleviation of graft-versus-host disease.
Abstract:A method of preparing swine donor tissue which includes hematopoietic stem cells and T cells for transplantation into a recipient mammal other than a swine. The method includes the swine donor tissue with an antibody which binds the epitope recognized by the mAb 2-6-15 monoclonal antibody. The binding facilitates depletion of T cells about as efficiently or more efficiently than does the mAb 2-6-15 monoclonal antibody and results in about the same or less depletion of stem cells as does the mAb 2-6-15 monoclonal antibody.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5843425
Application Number:US1995000461693
Date Filed:05/06/1995
Date Published:01/12/1998
Assignee:The General Hospital Corporation, Boston, MA, USA


 
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