Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5843438

Title:Peripheralization of hematopoietic stem cells
Inventors:Papayannopoulou, Thalia; Seattle, WA, USA
Summary:This invention describes a method of peripheralizing CD34+ hematopoietic stem cells in vivo via the administering of an anti-VLA-4 antibody or an anti-VCAM-1 antibody which blocks the binding of VLA-4 antigen on the surface of the CD34+ cells to VCAM or fibronectin. Also disclosed are methods of in vivo peripheralization of the CD34+ cells by administering anti-VLA-4 antibodies or anti-VCAM-1 antibodies.
Abstract:The invention relates to in vivo peripheralization of CD34.sup.+ cells by administering anti-VLA-4 antibodies or anti-VCAM-1 antibodies.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5843438
Application Number:US1995000436339
Date Filed:13/07/1995
Date Published:01/12/1998
Assignee:Board of Regents of the University of Washington, Seattle, WA, USA


 
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