Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5846770

Title:DNA molecules encoding human chordin
Inventors:LaVallie, Edward R.; Tewksbury, MA, USA
Racie, Lisa A.; Acton, MA, USA
DeRobertis, Edward M.; Pacific Palisades, CA, USA
Summary:Described herein is an isolated nucleic acid encoding the human chordin polypeptide, methods and uses thereof. The invention relates to purified chordin proteins, the DNA molecules encoding the chordin proteins, methods of their production, and methods by which the proteins may be complexed with the growth factor-beta (TGF-?) superfamily of proteins. Therapeutic applications are included for wound healing and tissue repair, particularly in the treatment of bone, cartilage and other connective tissue defects and disorders, including the regeneration of cardiac, hepatic, neurological, pancreatic and renal tissue.
Abstract:Purified chordin proteins and processes for producing them are disclosed. DNA molecules encoding the chordin proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, brain, lung, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction inhibition of growth and/or differentiation of undifferentiated embryonic and stem cells. The proteins may be complexed with other proteins, particularly members of the transforming growth factor-beta superfamily of proteins.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5846770
Application Number:US1996000749169
Date Filed:14/11/1996
Date Published:08/12/1996
Assignee:Genetics Institute, Inc., Cambridge, MA, USA


 
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