Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5854207

Title:Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
Inventors:Lee, John C.; San Antonio, TX, USA
Yeh, Lee-Chuan C.; San Antonio, TX, USA
Summary:Described herein are methods and materials for inducing mammalian tissue formation with a mixture of morphogenic protein and a stimulatory factor. The invention relates to pharmaceutical compositions comprised of a morphogenic protein stimulatory factor (MPSF) for improving the tissue inductive activity of morphogenic proteins, particularly those belonging to the BMP protein family. Further disclosed are properties of an implantable morphogenic device containing a morphogenic protein and a MPSF disposed within a pharmaceutically acceptable carrier, and which is capable of inducing tissue formation in allogeneic and xenogeneic implants. Also included is a prosthetic device comprised of a prosthesis coated with a morphogenic protein and a MPSF, and methods by which this combination may be used to promote the in vivo integration of such an implantable prosthetic device to enhance the bond strength between the prosthesis and the existing target tissue at the joining site. Therapeutic applications are included for use in implants and on prostheses, in the repair of bone or cartilage defects, and in the treatment of tissue-degenerative diseases.
Abstract:
US Patent Website:Click Here for Full Text of Patent
Title Number:US5854207
Application Number:US1998000027873
Date Filed:23/02/1998
Date Published:29/12/1998
Assignee:Stryker Corporation, Kalamazoo, MI, USA


 
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