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| Title: | Stem cell inhibiting proteins |
| Inventors: | Craig, Stewart; Oxford, United Kingdom Hunter, Michael George; Buckinghamshire, United Kingdom Edwards, Richard Mark; Oxford, United Kingdom Czaplewski, Lloyd George; Oxford, United Kingdom Gilbert, Richard James; Oxford, United Kingdom |
| Summary: | Described herein are proteinaceous molecules with stem cell inhibitory activity. The invention relates to analogues of LD78 or MIP-1?a which have mutations to prevent or reduce multimer formation beyond certain stages such as a dodecamer. Claims of the invention include the inhibition of aggregate formations resulting in low molecular weight monomers or oligomers with improved solution properties. Therapeutic applications are included for the use of such stem cell inhibiting proteins in the treatment of tumors. |
| Abstract: | Proteinaceous molecules with stem cell inhibition activity are analogues of LD78 or MIP-1.alpha. which have mutations to prevent or reduce multimer formation beyond certain stages (for example a dodecamer). Aggregate formation is therefore inhibited, and the resulting low molecular weight monomers (or oligomers) have improved solution properties leading to enhanced productivity and greater therapeutic utility as stem cell protective agents, which are useful in tumour therapy. |
| US Patent Website: | Click Here for Full Text of Patent |
| Title Number: | US5856301 |
| Application Number: | US1995000450905 |
| Date Filed: | 26/05/1995 |
| Date Published: | 05/01/1999 |
| Assignee: | British Biotech Pharmaceuticals Limited, Oxford, United Kingdom |