Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5856301

Title:Stem cell inhibiting proteins
Inventors:Craig, Stewart; Oxford, United Kingdom
Hunter, Michael George; Buckinghamshire, United Kingdom
Edwards, Richard Mark; Oxford, United Kingdom
Czaplewski, Lloyd George; Oxford, United Kingdom
Gilbert, Richard James; Oxford, United Kingdom
Summary:Described herein are proteinaceous molecules with stem cell inhibitory activity. The invention relates to analogues of LD78 or MIP-1?a which have mutations to prevent or reduce multimer formation beyond certain stages such as a dodecamer. Claims of the invention include the inhibition of aggregate formations resulting in low molecular weight monomers or oligomers with improved solution properties. Therapeutic applications are included for the use of such stem cell inhibiting proteins in the treatment of tumors.
Abstract:Proteinaceous molecules with stem cell inhibition activity are analogues of LD78 or MIP-1.alpha. which have mutations to prevent or reduce multimer formation beyond certain stages (for example a dodecamer). Aggregate formation is therefore inhibited, and the resulting low molecular weight monomers (or oligomers) have improved solution properties leading to enhanced productivity and greater therapeutic utility as stem cell protective agents, which are useful in tumour therapy.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5856301
Application Number:US1995000450905
Date Filed:26/05/1995
Date Published:05/01/1999
Assignee:British Biotech Pharmaceuticals Limited, Oxford, United Kingdom


 
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