Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5858744

Title:Retroviral vector hybrids and the use thereof for gene transfer
Inventors:Baum, Christopher; Hamburg, Germany
Stocking-Harbers, Carol; Hamburg, Germany
Ostertag, Wolfram; Hamburg, Germany
Summary:This invention introduces a novel retroviral vector hybrid, methods and uses thereof. Specifically disclosed are replication-defective retroviral vector hybrids that are characterized by a U5 region and/or a tRNA primer binding site of MESV as the U5 region, and/or a tRNA primer binding site in the leader region, and the U3 and R regions from a Friend murine leukemia virus (F-MuLV) as the U3 and R regions in the 3'-LTR. Further claims of the invention include improved suitability for effective gene transfer into hematopoietic stem cells.
Abstract:Replication-defective retroviral vector hybrids which are characterized in that they contain a) the U5 region and/or tRNA primer binding site of MESV as the U5 region and/or tRNA primer binding site in the leader region and b) the U3 and R regions from a Friend murine leukaemia virus (F-MuLV) as the U3 and R regions in the 3'-LTR and which are particularly suitable for an effective gene transfer in haematopoietic stem cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5858744
Application Number:US1997000793610
Date Filed:07/03/1997
Date Published:12/01/1999
Assignee:Boehringer Mannheim GmbH, Mannheim, Germany


 
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