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Stem Cell Related Patent Number US5858744
| Title: | Retroviral vector hybrids and the use thereof for gene transfer | | Inventors: | Baum, Christopher; Hamburg, Germany
Stocking-Harbers, Carol; Hamburg, Germany
Ostertag, Wolfram; Hamburg, Germany | | Summary: | This invention introduces a novel retroviral vector hybrid, methods and uses thereof. Specifically disclosed are replication-defective retroviral vector hybrids that are characterized by a U5 region and/or a tRNA primer binding site of MESV as the U5 region, and/or a tRNA primer binding site in the leader region, and the U3 and R regions from a Friend murine leukemia virus (F-MuLV) as the U3 and R regions in the 3'-LTR. Further claims of the invention include improved suitability for effective gene transfer into hematopoietic stem cells. | | Abstract: | Replication-defective retroviral vector hybrids which are characterized in that they contain a) the U5 region and/or tRNA primer binding site of MESV as the U5 region and/or tRNA primer binding site in the leader region and b) the U3 and R regions from a Friend murine leukaemia virus (F-MuLV) as the U3 and R regions in the 3'-LTR and which are particularly suitable for an effective gene transfer in haematopoietic stem cells. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US5858744 | | Application Number: | US1997000793610 | | Date Filed: | 07/03/1997 | | Date Published: | 12/01/1999 | | Assignee: | Boehringer Mannheim GmbH, Mannheim, Germany |
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