Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5861315

Title:Use of stem cell factor and soluble interleukin-6 receptor for the ex vivo expansion of hematopoietic multipotential cells
Inventors:Nakahata, Tatsutoshi; Tokyo, Japan
Summary:Described herein is a method for the ex vivo expansion of multipotent hematopoietic cells via a process of culturing the cells in combination with cytokines, interleukin-6, soluble interleukin-6 receptor and a stem cell factor. The invention relates to gp130 signaling and its involvement in the proliferation, differentiation and terminal maturation of erythroid blood cells from human hematopoietic multipotent cells in the absence of erythropoietin. Therapeutic and experimental applications are included.
Abstract:Stem cell factor in combination with soluble interleukin-6 receptor, interleukin-6, for gp130 signaling, supports the proliferation, differentiation and terminal maturation of blood cells from normal human hematopoietic multipotential cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5861315
Application Number:US1996000732023
Date Filed:16/10/1996
Date Published:19/01/1999
Assignee:Amgen Inc., Thousand Oaks, CA, USA


 
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