Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5866373

Title:Polynucleotide encoding a human chemotactic protein
Inventors:Li, Haodong; Gaithersburg, MD, USA
Summary:This invention describes a DNA that encodes the human monocyte chemotactic protein-4, methods and uses thereof. Disclosed herein is an isolated polynucleotide, the RNA encoding it, associated antagonists, the recombinant techniques by which the polynucleotide is produced and the specific conditions under which it hybridizes. Therapeutic uses of the polynucleotide are included for stem cell mobilization, myeloprotection, neuronal protection, and for applications in the treatment of tumors, the promotion of wound healing, the prevention of parasitic infections and the regulation of hematopoiesis. Specific applications of the antagonists are included for the treatment of rheumatoid arthritis, lung inflammation, allergy, infectious diseases, inflammation and atherosclerosis. Further disclosed are diagnostic assays for identifying mutations in nucleic acid sequences encoding such polypeptides and uses thereof in the identification of altered levels of the polypeptides in the detection of disease.
Abstract:A human chemotactic protein polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating for stem cell mobilization, myeloprotection and neuronal protection, to treat tumors, to promote wound healing, to combat parasitic infection and to regulate hematopoiesis. Also disclosed are antagonists against such polypeptides which may be employed to treat rheumatoid arthritis, lung inflammation, allergy, infectious diseases and to prevent inflammation and atherosclerosis. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5866373
Application Number:US1995000479126
Date Filed:07/06/1995
Date Published:02/02/1999
Assignee:Human Genome Sciences, Inc., Rockville, MD, USA

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