Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5874301

Title:Embryonic cell populations and methods to isolate such populations
Inventors:Keller, Gordon M.; Denver, CO, USA
Hawley, Robert G.; Toronto, Canada
Choi, Kyunghee; Baltimore, MD, USA
Summary:This invention introduces a population of immortalized pluripotent precursor cells that are derived from embryonic stem cell populations and which have been transformed with a HOX11 gene. Further disclosed are methods and materials by which the cell population differentiates into cellular lineages including primitive and definitive erythroid cells. Therapeutic applications are included for the treatment of genetic diseases in hematopoietic lineage cells such as sickle cell anaemia and b-thalassemia.
Abstract:The present invention relates to novel immortalized precursor cell populations derived from embryonic stem cell populations and methods to produce such cell populations. Also disclosed is an assay to identify regulatory compounds capable of controlling cell growth for therapeutic and experimental use.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5874301
Application Number:US1995000570211
Date Filed:11/12/1995
Date Published:23/02/1999
Assignee:National Jewish Center for Immunology and Respiratory Medicine, Denver, CO, USA


 
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