Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5905041

Title:Process for preparing and cultivating hematopoietic progenitor cells
Inventors:Beug, Hartmut; Vienna, Austria
Wessely, Oliver; Vienna, Austria
Steinlein, Peter; Vienna, Austria
Deiner, Eva; Vienna, Austria
Von Lindern, Maartje Marie; Vienna, Austria
Summary:This invention introduces a process for the in vitro expansion of non-immortalized hematopoietic CD34+ progenitor cells of erythroid lineage without simultaneous differentiation. Described herein are preparations of such erythroid lineage precursor cells that are grown in a medium containing a hormone and ligands for tyrosine kinase receptors, such that the non-immortalized progenitor cells are contacted with a combination of growth factors containing a glucocorticoid and an estrogen and at least one ligand of a tyrosine kinase receptor until the cells begin self-renewal. Therapeutic applications are included for the treatment of cancer, AIDS and anemia.
Abstract:
US Patent Website:Click Here for Full Text of Patent
Title Number:US5905041
Application Number:US1996000604990
Date Filed:29/04/1996
Date Published:18/05/1999
Assignee:Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany


 
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