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| Title: | Process for preparing and cultivating hematopoietic progenitor cells |
| Inventors: | Beug, Hartmut; Vienna, Austria Wessely, Oliver; Vienna, Austria Steinlein, Peter; Vienna, Austria Deiner, Eva; Vienna, Austria Von Lindern, Maartje Marie; Vienna, Austria |
| Summary: | This invention introduces a process for the in vitro expansion of non-immortalized hematopoietic CD34+ progenitor cells of erythroid lineage without simultaneous differentiation. Described herein are preparations of such erythroid lineage precursor cells that are grown in a medium containing a hormone and ligands for tyrosine kinase receptors, such that the non-immortalized progenitor cells are contacted with a combination of growth factors containing a glucocorticoid and an estrogen and at least one ligand of a tyrosine kinase receptor until the cells begin self-renewal. Therapeutic applications are included for the treatment of cancer, AIDS and anemia. |
| Abstract: | |
| US Patent Website: | Click Here for Full Text of Patent |
| Title Number: | US5905041 |
| Application Number: | US1996000604990 |
| Date Filed: | 29/04/1996 |
| Date Published: | 18/05/1999 |
| Assignee: | Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany |