Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5906984

Title:Methods of using aminothiols to promote hematopoietic progenitor cell growth
Inventors:Capizzi, Robert L.; Haverford, PA, USA
List, Alan F.; Tucson, AZ, USA
Summary:Described herein are methods of stimulating hematopoietic progenitor cells via the administration of thiol compounds selected from the group consisting of S-2-(3-aminopropylamino) ethyl dihydrogen phosphorothioate (WR 2721), 1-propanethiol-3-[[3-(methylamino)propyl]amino]-dihydrogen phosphorothioate (WR 151327), 2-[(3-aminopropyl)amino]-ethanethiol (WR 1065), and 3-[[3-(methylamino)propyl]amino]-1-propanethiol (WR 151326), or a pharmaceutically acceptable salt, hydrate or solvate thereof. Therapeutic applications are included for the treatment of marrow failure and immunodeficient conditions such myelodysplastic syndromes and acquired immunodeficiency syndrome.
Abstract:The present invention relates to methods of stimulating he growth of hematopoietic progenitor cells. In particular, it relates to the use of thiols and related compounds in stimulating the growth of hematopoietic progenitor cells in vitro and in vivo. Furthermore, the present invention relates to methods of using these compounds for the treatment of marrow failure states and immunodeficient conditions, including but not limited to myelodysplastic syndromes and acquired immunodeficiency syndrome.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5906984
Application Number:US1998000046870
Date Filed:24/03/1998
Date Published:25/05/1999
Assignee:Arizona Board of Regents on behalf of The University of Arizona, Tucson, AZ, USA U.S. Bioscience, West Conshohocken, PA, USA


 
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