Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5912133

Title:Method for isolating stem cells expressing flk-1 receptors
Inventors:Lemischka, Ihor R.; Princeton, NJ, USA
Summary:Described herein are methods of isolating hematopoietic cells that express the fetal liver kinase 1 (FLK-1) receptors on their surface. The invention relates to isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells and not expressed in mature hematopoietic cells. Further disclosed are properties of the receptors encoded by such nucleic acid molecules, and methods of stimulating the proliferation or differentiation of primitive mammalian hematopoietic stem cells via a process of contacting the stem cells with a ligand that binds to a receptor protein tyrosine kinase expressed in the primitive hematopoietic cells but not expressed in mature hematopoietic cells. Therapeutic and experimental applications are included.
Abstract:Isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells and not expressed in mature hematopoietic cells are provided. Also included are the receptors encoded by such nucleic acid molecules; the nucleic acid molecules encoding receptor protein tyrosine kinases having the sequences shown in FIG. 1a (murine flk-2), FIG. 1b (human flk-2) and FIG. 2 (murine flk-1); the receptor protein tyrosine kinases having the amino acid sequences shown in FIG. 1a, FIG. 1b and FIG. 2; ligands for the receptors; nucleic acid sequences that encode the ligands; and methods of stimulating the proliferation and/or differentiation of primitive mammalian hematopoietic stem cells comprising contacting the stem cells with a ligand that binds to a receptor protein tyrosine kinase expressed in primitive mammalian hematopoietic cells and not expressed in mature hematopoietic cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5912133
Application Number:US1998000021324
Date Filed:10/02/1998
Date Published:15/06/1999
Assignee:The Trustees of Princeton University, Princeton, NJ, USA


 
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