Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5914268

Title:Embryonic cell populations and methods to isolate such populations
Inventors:Keller, Gordon M.; Denver, CO, USA
Kennedy, Marion; Denver, CO, USA
Choi, Kyunghee; Denver, CO, USA
Firpo, Meri T.; Denver, CO, USA
Summary:Described herein are pluripotent embryonic stem cell populations, and methods of their isolation and production. The invention relates to novel pluripotent embryonic cell populations having the capacity to develop into cells of hematopoietic and endothelial lineages, as well as into primitive erythroid cells, definitive erythroid cells, macrophages, neutrophils, mast cells, T cells, B cells, natural killer cells, megakaryocytes, eosinophils, progenitor cells and progeny thereof. Methods of culturing are provided for obtaining an embryoid body cell population which in turn is cultured under conditions effective to produce a pluripotent cell population. Therapeutic and experimental applications include techniques for identifying embryonic cell compounds.
Abstract:The present invention relates to novel pluripotent embryonic cell populations derived from embryonic stem cell populations and methods to produce such pluripotent embryonic cell populations. Disclosed is an embryonic stem cell-derived pluripotent embryoid body cell population having one or more cells capable of developing into cells of hematopoietic and/or endothelial lineage. Also disclosed is an embryoid body cell population-derived mixed population of endothelial and erythroid cells. Also disclosed is an embryoid body cell population-derived embryonic blast cell population capable of developing into a variety of hematopoietic cell types. The invention is additionally directed to embryonic stem cell population-derived T and B cell populations. Methods to identify embryonic cell compounds are also disclosed for therapeutic and experimental use.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5914268
Application Number:US1994000343686
Date Filed:21/11/1994
Date Published:22/06/1999
Assignee:National Jewish Center for Immunology and Respiratory Medicine, Denver, CO, USA

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