Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5925568

Title:Release and mobilization of haematopoietic cells
Inventors:Comer, Michael Berisford; Oxford, United Kingdom
McCourt, Matthew John; Oxford, United Kingdom
Wood, Lars Michael; Oxford, United Kingdom
Hunter, Michael George; Oxford, United Kingdom
Edwards, Richard Mark; Oxford, United Kingdom
Summary:Described herein are novel uses of stem cell inhibitors for promoting the release and mobilization of hematopoietic cells from mammalian marrow. The invention relates to stem cell inhibitors such as murine and human macrophage inflammatory protein-1alpha (muMIP-1alpha and huMIP-1alpha/LD78), and analogues and variants thereof, and methods of their use in the harvesting of hematopoietic cells prior to autologous or heterologous transportation. Therapeutic applications are included in the enhancement of responses against infection, and in the treatment and prevention of neutropenia.
Abstract:Stem cell inhibitors such as murine and human macrophage inflammatory protein-1alpha (muMIP-1alpha and huMIP-1alpha/LD78) and their analogues and variants enhance the release and mobilization of haematopoietic cells. This property makes them useful in enhancing responses against infection and in cell harvesting.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5925568
Application Number:US1996000545587
Date Filed:16/01/1996
Date Published:20/07/1999
Assignee:British Biotech Pharmaceuticals Limited, Oxford, United Kingdom


 
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