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Stem Cell Related Patent Number US5928888
| Title: | Methods and compositions for sensitive and rapid, functional identification of genomic polynucleotides and secondary screening capabilities | | Inventors: | Whitney, Michael A.; La Jolla, CA | | Summary: | This invention provides for methods and compositions for identifying proteins or compounds that directly or indirectly modulate a genomic polynucleotide. Also disclosed are methods for identifying active genomic polynucleotides themselves. Procedures involve inserting a BL (beta-lactamase) expression construct into an eukaryotic genome, usually non-yeast, contained in at least one living cell, contacting the cell with a predetermined concentration of a modulator, and detecting BL activity in the cell. | | Abstract: | The invention provides for a methods and compositions for identifying proteins or compounds that directly or indirectly modulate a genomic polynucleotide and methods for identifying active genomic polynucleotides. Generally, the method comprises inserting a BL (beta-lactamase) expression construct into an eukaryotic genome, usually non-yeast, contained in at least one living cell, contacting the cell with a predetermined concentration of a modulator, and detecting BL activity in the cell. | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US5928888 | | Application Number: | US1996000719697 | | Date Filed: | 26/09/1996 | | Date Published: | 27/07/1999 | | Assignee: | Aurora Biosciences Corporation, San Diego, CA, USA |
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