Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5928888

Title:Methods and compositions for sensitive and rapid, functional identification of genomic polynucleotides and secondary screening capabilities
Inventors:Whitney, Michael A.; La Jolla, CA
Summary:This invention provides for methods and compositions for identifying proteins or compounds that directly or indirectly modulate a genomic polynucleotide. Also disclosed are methods for identifying active genomic polynucleotides themselves. Procedures involve inserting a BL (beta-lactamase) expression construct into an eukaryotic genome, usually non-yeast, contained in at least one living cell, contacting the cell with a predetermined concentration of a modulator, and detecting BL activity in the cell.
Abstract:The invention provides for a methods and compositions for identifying proteins or compounds that directly or indirectly modulate a genomic polynucleotide and methods for identifying active genomic polynucleotides. Generally, the method comprises inserting a BL (beta-lactamase) expression construct into an eukaryotic genome, usually non-yeast, contained in at least one living cell, contacting the cell with a predetermined concentration of a modulator, and detecting BL activity in the cell.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5928888
Application Number:US1996000719697
Date Filed:26/09/1996
Date Published:27/07/1999
Assignee:Aurora Biosciences Corporation, San Diego, CA, USA


 
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