Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5936067

Title:Macrophage inflammatory protein variants
Inventors:Graham, Gerard; Glasgow, United Kingdom
Pragnell, Ian; Glasgow, United Kingdom
Summary:Described herein are novel stem cell inhibitor macrophage protein variants characterized by amino acid alterations from the active form. Claims of the invention include the retention of substantially unaltered stem cell inhibitory activity and reduced aggregation. Specific amino acid sequences are disclosed, as are therapeutic applications in the protection of stem cells during cancer therapy.
Abstract:The present invention provides a Stem Cell Inhibitor (SCT) protein which comprises at least one amino acid alteration from its active form which protein does not significantly aggregate but which retains substantially unaltered stem cell inhibitory activity. The alteration is preferably a conservative substitution of a charged amino acid residue. Such proteins may be used in treating stem cells in a patient undergoing chemotherapy.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5936067
Application Number:US1996000535116
Date Filed:29/01/1996
Date Published:10/08/1999
Assignee:Genetics Institute, Inc., Cambridge, MA, USA


 
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