Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5942225

Title:Lineage-directed induction of human mesenchymal stem cell differentiation
Inventors:Bruder, Scott P.; Owings Mills, MD, USA
Caplan, Arnold I.; Cleveland Heights, OH, USA
Haynesworth, Stephen E.; Cleveland Heights, OH, USA
Summary:Described herein is a composition for the in vitro and ex vivo induction of lineage-directed differentiation of isolated human mesenchymal stem cells. The invention relates to methods by which the cells are expanded into a single lineage comprised of mesenchymal stem cells and one or more bioactive factors. Further disclosed are methods of contacting the cells with factors that induce differentiation into specific lineages, and properties of those factors. Therapeutic applications in the regeneration and repair of mesenchymal tissue are included.
Abstract:Methods for in vitro or ex vivo lineage directed induction of isolated, culture expanded human mesenchymal stem cells comprising contacting the mesenchymal stem cells with a bioactive factor effective to induce differentiation thereof into a lineage of choice as well as such compositions including isolated culture expanded human mesenchymal stem cells and bioactive factors effective to induce directed lineage induction are disclosed. Further disclosed is this method which also includes introducing such culturally expanded lineage-induced mesenchymal stem cells into a host from which they have originated for purposes of mesenchymal tissue regeneration or repair.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5942225
Application Number:US1997000899414
Date Filed:23/07/1997
Date Published:24/08/1999
Assignee:Case Western Reserve University, Cleveland, OH, USA Osiris Therapeutics, Inc., Baltimore, MD, USA


 
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