Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5942435

Title:Transgenic swine compositions and methods
Inventors:Wheeler, Matthew B.; Tolono, IL, USA
Summary:Described herein are chimeric and transgenic swine ungulates, methods and uses thereof. The invention relates to porcine (Sus scrofa) embryonic stem cell lines and methods of their establishment and transformation via exogenous genetic material and germ cells comprising the genetic material. Further disclosed are methods by which the chimeric swine are bred to provide transgenic swine, which in turn offer therapeutic applications as xenograft donors and in the production of human proteins and peptide hormones.
Abstract:Transgenic swine, and compositions and methods for making and using same, are provided. Central to the invention are porcine (Sus scrofa) embryonic stem cell lines and methods for establishing them. Cells of such lines are transformed with exogenous genetic material of interest and then used to provide chimeric swine, which have germ cells comprising the exogenous genetic material. The chimeric swine are bred to provide transgenic swine. Transgenic swine of the invention can be used to provide human proteins or peptide hormones or can be used as xenograft donors.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5942435
Application Number:US1995000473030
Date Filed:06/06/1995
Date Published:24/08/1999
Assignee:The Board of Trustees of the University of Illinois, Urbana-Champaign, IL, USA Biotechnology Research and Development Corp., Peoria, IL, USA


 
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