Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5942496

Title:Methods and compositions for multiple gene transfer into bone cells
Inventors:Bonadio, Jeffrey; Ann Harbor, MI, USA
Goldstein, Steven A.; Ann Harbor, MI, USA
Summary:Described herein are methods and materials for transferring nucleic acid into bone progenitor cells in situ. The invention relates to methods by which a composition comprised of two or more nucleic acid segments and a structural bone-compatible matrix are contacted in situ with the mammalian tissue, such that the nucleic acid segments are transferred into the cells, resulting in the expression of transcriptional or translational products within the cells that are encoded by the nucleic aid segments. Further disclosed are properties of Type II collagen and osteotropic genes, and the gene transfer protocols by which they stimulate bone progenitor cells and promote bone growth, repair and regeneration in vivo. Therapeutic applications are included in the treatment of various bone-related diseases and defects including fractures, osteoporosis, osteogenesis imperfecta, and in the use of bone implants.
Abstract:
US Patent Website:Click Here for Full Text of Patent
Title Number:US5942496
Application Number:US1994000316650
Date Filed:30/09/1994
Date Published:24/08/1999
Assignee:The Regent of the University of Michigan, Ann Arbor, MI, USA


 
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