Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5948278

Title:System and method for enrichment of rare cell population from whole blood samples
Inventors:Sammons, David W.; Tucson, AZ, USA
Manley, Michael; Tucson, AZ, USA
Utermohlen, Joseph G.; Tucson, AZ, USA
Twitty, Garland E.; Tucson, AZ, USA
Summary:Described herein is a novel system for the enrichment of cell populations, especially fetal cells, from whole blood. The invention relates to the depletion of unwanted cells via methods of density gradient separation in a charged-flow separator. The rare cell fractions are separated from a whole blood sample according to the relative charge density and/or the relative binding affinity for a leukocyte depletion solid phase matrix. Methods are further provided by which the process of enrichment may be operated as a stand-alone process, or as a pre- or post-processing step in conjunction with the charge-flow separation method. Also disclosed are methods by which the cell population is selected from a group consisting of nucleated cells, erythroid progenitor cells and fetal nucleated erythrocytes within the whole blood sample.
Abstract:A method for enriching rare cell populations from a whole blood sample by separating rare cell fractions from whole blood sample according to the relative charge density and/or the relative binding affinity for a leukocyte depletion solid phase matrix is described. The enrichment method may be operated stand alone, or as a pre or post-processing step in conjunction with a charge-flow separation method.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5948278
Application Number:US1997000949240
Date Filed:10/10/1997
Date Published:07/09/1999
Assignee:BioSeparations, Inc., Tucson, AZ, USA


 
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