Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5948640

Title:Mammalian additional sex combs (mammalian Asx) acts as a tumor suppressor
Inventors:Randazzo, Filippo M.; Emeryville, CA, USA
Summary:Described herein is an isolated nucleic acid molecule encoding a mammalian Asx polypeptide, as well as associated vectors and modulators. Various embodiments of the invention disclose properties of the host cell that is either a bacterial, yeast, insect, amphibian or mammalian cell. Therapeutic and diagnostic applications are directed toward proliferative and developmental disorders, including the screening of anti-proliferative compounds for inducing de-differentiation and dysregulation of cells. Applications of the Asx modulators in cancer therapy are also provided.
Abstract:
US Patent Website:Click Here for Full Text of Patent
Title Number:US5948640
Application Number:US1997000853310
Date Filed:08/05/1997
Date Published:07/09/1999
Assignee:Chiron Corporation, Emeryville, CA, USA


 
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