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Stem Cell Related Patent Number US5948640
| Title: | Mammalian additional sex combs (mammalian Asx) acts as a tumor suppressor | | Inventors: | Randazzo, Filippo M.; Emeryville, CA, USA | | Summary: | Described herein is an isolated nucleic acid molecule encoding a mammalian Asx polypeptide, as well as associated vectors and modulators. Various embodiments of the invention disclose properties of the host cell that is either a bacterial, yeast, insect, amphibian or mammalian cell. Therapeutic and diagnostic applications are directed toward proliferative and developmental disorders, including the screening of anti-proliferative compounds for inducing de-differentiation and dysregulation of cells. Applications of the Asx modulators in cancer therapy are also provided. | | Abstract: | | | US Patent Website: | Click Here for Full Text of Patent | | Title Number: | US5948640 | | Application Number: | US1997000853310 | | Date Filed: | 08/05/1997 | | Date Published: | 07/09/1999 | | Assignee: | Chiron Corporation, Emeryville, CA, USA |
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