Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5948645

Title:Biosynthetic gene muri from Streptococcus pneumoniae
Inventors:Hoskins, Jo Ann; Indianapolis, IN, USA
Norris, Franklin Harpold; Indianapolis, IN, USA
Rockey, Pamela Kay; Indianapolis, IN, USA
Rosteck, Jr., Paul Robert; Indianapolis, IN, USA
Skatrud, Paul Luther; Indianapolis, IN, USA
Treadway, Patti Jean; Greenwood, IN, USA
Bellido, Michele Louise Young; Indianapolis, IN, USA
Wu, Chyun-Yeh Earnest; Indianapolis, IN, USA
Summary:Described herein is a Streptococcus pneumoniae muri protein, methods and uses thereof. The invention relates to isolated nucleic acid compounds encoding the stem peptide biosynthetic gene muri of Streptococcus pneumoniae. Further disclosed are properties of vectors and transformed heterologous host cells for expressing the Muri enzyme product, as well as a method for identifying compounds that inhibit stem peptide biosynthesis. Therapeutic and experimental applications are included for antibacterial drug screening.
Abstract:The invention provides isolated nucleic acid compounds encoding the stem peptide biosynthetic gene murI of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the MurI enzyme product and a method for identifying compounds that inhibit stem peptide biosynthesis.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5948645
Application Number:US1996000759907
Date Filed:04/12/1996
Date Published:07/09/1999
Assignee:Eli Lilly and Company, Indianapolis, IN, USA


 
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