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| Title: | Biosynthetic gene muri from Streptococcus pneumoniae |
| Inventors: | Hoskins, Jo Ann; Indianapolis, IN, USA Norris, Franklin Harpold; Indianapolis, IN, USA Rockey, Pamela Kay; Indianapolis, IN, USA Rosteck, Jr., Paul Robert; Indianapolis, IN, USA Skatrud, Paul Luther; Indianapolis, IN, USA Treadway, Patti Jean; Greenwood, IN, USA Bellido, Michele Louise Young; Indianapolis, IN, USA Wu, Chyun-Yeh Earnest; Indianapolis, IN, USA |
| Summary: | Described herein is a Streptococcus pneumoniae muri protein, methods and uses thereof. The invention relates to isolated nucleic acid compounds encoding the stem peptide biosynthetic gene muri of Streptococcus pneumoniae. Further disclosed are properties of vectors and transformed heterologous host cells for expressing the Muri enzyme product, as well as a method for identifying compounds that inhibit stem peptide biosynthesis. Therapeutic and experimental applications are included for antibacterial drug screening. |
| Abstract: | The invention provides isolated nucleic acid compounds encoding the stem peptide biosynthetic gene murI of Streptococcus pneumoniae. Also provided are vectors and transformed heterologous host cells for expressing the MurI enzyme product and a method for identifying compounds that inhibit stem peptide biosynthesis. |
| US Patent Website: | Click Here for Full Text of Patent |
| Title Number: | US5948645 |
| Application Number: | US1996000759907 |
| Date Filed: | 04/12/1996 |
| Date Published: | 07/09/1999 |
| Assignee: | Eli Lilly and Company, Indianapolis, IN, USA |