Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5958769

Title:Compositions and methods for mediating cell cycle progression
Inventors:Roberts, James M.; Seattle, WA, USA
Coats, Steven R.; Seattle, WA, USA
Fero, Matthew L.; Seattle, WA, USA
Summary:Described herein is a method for increasing the proportion of dividing cells in a vertebrate cell population. The invention relates to a hypertrophic variant organism with inactivated inhibitors of the p27 cyclin dependent kinase protein or sequences encoding the protein, and methods by which such proteins modulate vertebrate cell cycle progression. Further disclosed are conditions under which the proportion of dividing cells to non-dividing cells is shown to increase in a population of cells that have been treated with such proteins. Claims of the invention include an increased hematopoietic progenitor cell population with improved efficiency and utility in therapeutic and experimental application, which include the use of such cells as a model for the treatment of diseases caused by abnormal cell proliferation, such as hyperplasia.
Abstract:Inhibitors of the p27 cyclin dependent kinase inhibitor protein or sequences encoding the protein modulate vertebrate cell cycle progression and increase the proportion of dividing cells to non-dividing cells in a population of treated cells. As the proportion of dividing cells increases, the cell population, e.g., hematopoietic progenitor (stem) cells, is more efficiently used for gene therapy applications.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5958769
Application Number:US1996000588595
Date Filed:18/01/1996
Date Published:28/09/1999
Assignee:Fred Hutchinson Cancer Research Center, Seattle, WA, USA


 
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