Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5965403

Title:Nucleic acids encoding bone morphogenic protein-16 (BMP-16)
Inventors:Celeste, Anthony J.; Hudson, MA, USA
Murray, Beth L.; Arlington, MA, USA
Summary:Described herein are novel isolated nucleic acids encoding the bone morphogenetic protein-16 (BMP-16), methods and uses thereof. The invention relates to purified BMP-16 proteins and the DNA molecules encoding the BMP-16 proteins. Specific nucleotide and amino acid sequences are disclosed, as are therapeutic applications for the regeneration of bone, cartilage and other connective tissue, including cardiac, hepatic, pancreatic, neurological and renal tissue. This invention represents a continuation of other applications filed by the same assignee and inventors.
Abstract:Purified BMP-16 proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-16 proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, lung, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction of growth and/or differentiation of undifferentiated embryonic and stem cells.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5965403
Application Number:US1996000715202
Date Filed:18/09/1996
Date Published:12/10/1999
Assignee:Genetics Institute, Inc., Cambridge, MA, USA


 
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