Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5965436

Title:Method of isolating mesenchymal stem cells associated with isolated megakaryocytes by isolating megakaryocytes
Inventors:Thiede, Mark A.; Forest Hills, MD, USA
Marshak, Daniel R.; Lutherville, MD, USA
Summary:This invention introduces methods for the recovery of human mesenchymal stem cells (hMSCs) from tissue via a process of isolating and separating megakaryocyte populations. Further disclosed are methods of purifying and culturally expanding the hMSCs that are associated with the megakaryocyte precursors, such as those found in bone marrow. Therapeutic applications are included for the regeneration of damaged tissue and for the assay and isolation of growth or differentiation factors.
Abstract:The present invention is directed to isolated and purified human mesenchymal stem cells, to a method for isolating, purifying, and culturally expanding human mesenchymal stem cells (i.e. mesenchymal stem cells or MSCs), and to the characterization of and uses for such cells. In particular, the invention relates to isolation of MSCs that are associated with hematopoietic cells, such as megakaryocyte precursors, in the bone marrow.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5965436
Application Number:US1997000969260
Date Filed:13/11/1997
Date Published:12/10/1999
Assignee:Osiris Therapeutics, Inc., Baltimore, MD, USA


 
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