Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5965437

Title:Method of screening a compound for hematopoietic activity
Inventors:Scadden, David T.; Weston, MA, USA
Summary:Described herein are methods of screening a compound for hematopoietic activity. The invention relates to the selection of a population of human cells containing quiescent pluripotent hematopoietic progenitor cells that are substantially free of mature, human myeloid and lymphoid cells. Further disclosed are methods by which a population of quiescent pluripotent progenitor cells are obtained and contacted with various factors including at least one anti-metabolite agent and at least one early-acting growth factor. Culture conditions are provided, as are therapeutic applications to the treatment of a variety of hematopoietic disorders.
Abstract:Methods of selecting a population of human cells containing quiescent pluripotent hematopoietic progenitor cells substantially free of mature, human myeloid and lymphoid cells, the quiescent pluripotent progenitor cells obtained by these methods, and methods of using the pluripotent progenitor cells are described.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5965437
Application Number:US1998000107737
Date Filed:30/06/1998
Date Published:12/10/1999
Assignee:Beth Israel Deaconess Medical Center, Boston, MA, USA


 
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