Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5969105

Title:Stem cell factor receptor agonists
Inventors:Feng, Yiqing; St. Louis, MO, USA
McWherter, Charles A.; Wildwood, MO, USA
Summary:This invention introduces novel human stem cell factor receptor agonist polypeptides, methods and uses thereof. Further disclosed are the nucleic acid molecules encoding the human stem cell factor receptor agonist polypeptides, which are derived from the sequence of SEQ ID NO:1, wherein the amino acids 1 to 23 are optionally deleted from the C-terminus, while the N-terminus is described as having been joined to the C-terminus either directly or through a linker such that C- and N-termini are created between an amino acid pair chosen from 23-24 through 110-111 of SEQ ID NO:1, which results in the generation of the human stem cell factor receptor agonist polypeptide, which in turn may be immediately preceded by methionine-1, alanine-1 or methionine-2, alanine-1. Therapeutic applications are included for stimulating the production of hematopoietic cells and for the treatment of tumors, infection or autoimmune disease.
Abstract:The present invention is drawn to human stem cell factor receptor agonist polypeptides, nucleic acid molecules encoding same, methods of producing the agonist polypeptides from the nucleic acid sequences and therapeutic compositions comprising the agonist polypeptides. The polypeptides of the instant invention are derived from the sequnce of SEQ ID NO:1, wherein 1-23 amino acids are optionally deleted from the C-terminus and the N-terminus is joined to the C-terminus, either directly or through a linker and C- and N-termini are created between an amino acid pair chosen from 23-24 through 110-111 of SEQ ID NO:1, generating said human stem cell factor receptor agonist polypeptide. The human stem cell factor receptor agonist polypeptide may additionally be immediately be preceded by a (methionine.sup.-1), (alanine.sup.-1) or (methionine.sup.-2, alanine.sup.-1).
US Patent Website:Click Here for Full Text of Patent
Title Number:US5969105
Application Number:US1997000955848
Date Filed:21/10/1997
Date Published:19/10/1999
Assignee:None


 
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