Methods comprising apoptosis inhibitors for the generation of transgenic pigs

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Stem Cell Related Patent Number US5972627

Title:Method of purifying a population of cells enriched for dendritic and/or lymphoid progenitors and populations of cells obtained thereby
Inventors:Galy, Anne H. M.; Palo Alto, CA, USA
Summary:Described herein are novel compositions enriched for hematopoietic progenitor cells, methods and uses thereof. The invention relates to processes of enriching hematopoietic cell populations in myeloid and lymphoid progenitor cells based on cell-specific markers, thereby also providing an enriched population of prethymic lymphoid-committed progenitor cells lacking long-term hematopoietic reconstitution potential. Methods by which the cells may be genetically modified are also provided. Therapeutic applications are included for the identification of biological response modifiers and for gene therapy.
Abstract:The invention relates to methods of enriching for hematopoietic cell populations enriched in myeloid and/or lymphoid progenitor cells based on cell specific markers. The methods also provide an enriched population of prethymic lymphoid-committed progenitor population lacking long-term hematopoietic reconstitution potential. Compositions enriched for the cells and populations of cells obtained therefrom are also provided by the invention. Methods of use of the cells are also included. Methods of genetically modifying the cells are provided as are cells obtained thereby.
US Patent Website:Click Here for Full Text of Patent
Title Number:US5972627
Application Number:US1995000476403
Date Filed:07/06/1995
Date Published:26/10/1999
Assignee:SyStemix, Inc., Palo Alto, CA, USA


 
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